PDPK1 - What does PDPK1 stand for? The Free Dictionary
References in periodicals archive
The proliferative effect is mediated through PDPK1
overexpression, increased AKT phosphorylation, and PTEN suppression, while resistance to apoptosis results from enhanced expression of B-cell lymphoma-extra large (Bcl-xL) and cyclooxygenase-2 (COX-2).
Corbo et al (15) analyzed 36 primary PanNETs and found no mutations in 6 key genes in the mTOR pathway (AKT2, PIK3CA, RPS6K1, STK11, PDPK1
, and FRAPl-mTOR).
Genetic inactivation of AKT1, AKT2, and PDPK1
in human colorectal cancer cells clarifies their roles in tumor growth regulation.