PDPK1Phosphoinositide Dependent Protein Kinase-1
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References in periodicals archive ?
The proliferative effect is mediated through PDPK1 overexpression, increased AKT phosphorylation, and PTEN suppression, while resistance to apoptosis results from enhanced expression of B-cell lymphoma-extra large (Bcl-xL) and cyclooxygenase-2 (COX-2).
Corbo et al (15) analyzed 36 primary PanNETs and found no mutations in 6 key genes in the mTOR pathway (AKT2, PIK3CA, RPS6K1, STK11, PDPK1, and FRAPl-mTOR).
Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.