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Property Description logP Octanol-water partition coefficient logD Octanol-water distribution coefficient Peff Human effective jejunal permeation in cm/s x [10.sup.4] Sw Aqueous solubility in mg/mL Vd Volume of distribution in L/kg RBP Blood-to-plasma concentration ratio F up Percent of drug unbound to plasma protein Property Recommended range ZYZ-488 LEO logP <4.5 -0.89 0.89 logD <3.5 -0.89 -0.2 Peff [greater than or equal to]0.1 0.18 0.32 Sw [greater than or equal to] 0.010 11.4 6.06 Vd <3.7 0.51 1.05 RBP <1.0 0.81 0.89 F up >2%, <95% 41.86 38.23 Table 3: Prediction of various isoforms of phase I and phase II metabolism enzyme.
Table 1 summarizes the settings of the experiments that varied according to the convective scheme (Grell and MIT-Emanuel), minimum relative humidity for formation of cloud in scale grid ([RH.sub.min]), and the dynamic control (closure) of Grell model (Arakawa-Schubert or Fritsch-Chappell); in addition different PEFF are used if the scheme was the Grell convective.
Statistical significance in the Papp, Peff values, pharmacokinetic parameters and toxicity index obtained from various treatment groups was estimated by the analysis of variance (Student's t-test) or one-way ANOVA.
Hasan and Matron (2003) reported that the higher presence of foreign banks in Hungary have created a more competitive environment, impacted overall performance, and enhanced the profit efficiency (PEFF) of all banks in the country.
KONE Inc., one of the worldOs leading elevator and escalator companies, and Power Efficiency Corporation (OTCBB: PEFF - News), a clean tech company focused on energy efficiency technologies for electric motors, announced today that KONE has installed the EcoStart[umlaut] on escalators at McCarran International Airport (LAS).
(11.) Balduini FC, Peff TC, Torg JS: Application of electrothermal energy in arthroscopy.
This footage will screen at the PEFF. That has been made possible thanks to the cooperation of the Institut Lumiere.
Attle, Sue Babel, Sammy Bayes, Robert Berdeen, Lorenzo Bianco, Duane Bodin, Robert Currie, Sarah Felcher, Tony Gardell, Louis Genevrino, Ross Gifford, Dan Jasin, Sandra Kazan, Thom Koutsoukas, Sharon Lerit, Sylvia Mama, Peff Modelski, Irene Paris, Charles Rule, Carol Sawyer, Roberta Senn, Mitch Thomas, Helen Verbit.
Master teachers such as David Howard, Suki Schorer, Peff Modelski, Adrienne Dellas, and Diana Byer offer insights into their training philosophies, while a healthy cross-section of company schools and private studios discuss their various training methods (sample pointe classes included).
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- Peffer Western Environmental Education Program