PEITCPhenylethyl Isothiocyanate
PEITCPublic Education Information Technology Committee (Idaho)
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Washington, Aug 3 ( ANI ): A new study by researchers, including one of Indian origin, has found that the natural plant compound phenethyl isothiocyanate (PEITC) hinders the development of mammary tumours in a mouse model with similarities to human breast cancer progression.
Phenethyl isothiocyanate (PEITC) is a member of isothiocyanate distributed as gluconasturtiin in some cruciferous plants including broccoli, cabbage, cauliflower, horseradish, and watercress [105].
In a study released in May 2013, PEITC was found to suppress a compound known as PCAF (P300/CBP-associated factor)--which in turn inhibits androgen receptor-regulated transcriptional activity in prostate cancer cells.
Similarly compounds such as PEITC and sulforaphane have also been shown to have prostate cancer preventive properties in both in vitro and in vivo models (Singh et al.
The chemical in watercress that makes it taste peppery - phenyethyl isothiocyanate, or PEITC - prevented cell damage.
For example, the cancer preventive effects of allium species (e.g., garlic) and cruciferous vegetables (e.g., broccoli and watercress) are attributed to organosulfur compounds (e.g., diallyl trisulfide) and isothiocyanates (e.g., sulforaphane (SFN) and phenethyl isothiocyanate (PEITC)), respectively [56].
After the discovery of plant-derived compound called Phenethylisothiocyanate, or PEITC, which showed potential anti-inflammatory activities, Moul Dey from South Dakota State University will now examine the potential use of this plant extract against colon cancer.
(2007) observed in vitro that phenethyl isothiocyanate (PEITC) binds covalently to cellular proteins and induces apoptosis in cancer cell lines.
Another study, also at the University of Pittsburgh, found phenyl isothiocyanate (PEITC) - found in broccoli and cabbage - was extremely effective at combating ovarian cancer.