Although PEXS is primarily an ocular disease, the accumulation of the abnormal pseudoexfoliation material has also been observed in extraocular tissues including the heart, lungs, kidneys, liver, gall bladder and brain (11, 12).
Our findings also have importance from the point of cardiovascular prognosis in patients with PEXS.
4), the acute (hemorrhages, embolus, thromboses) and chronic (cerebral atrophy, cerebral ischemia, senile dementia) cerebrovascular events are reported to be observed more frequently in PEXS patients.
3) among subjects 50 years or older, PEXS was found to be positively associated with the risk for coronary artery disease.
24) PEXS was reported to impair the endothelial function and cause structural vessel wall abnormality.
The results of our study suggest that increased aortic stiffness may be at least partially responsible for the increased incidence of coronary artery disease observed in patients with PEXS.