PF4


Also found in: Medical.
AcronymDefinition
PF4Platelet Factor Four (molecular biology)
PF4Plasma Factor 4 (neurosurgery)
References in periodicals archive ?
The platelets bind to the human red cells, containing the malaria parasites, and kill the parasites by releasing into the red cell PF4.
Operating points Operating air flow gas temperature point (kg/h) ([degrees]C) PF1 75.0 165 PF2 75.0 180 PF3 75.0 195 PF4 130.0 165 PF5 130.0 180 PF6 130.0 195 Table 4.
Overall, the Pf4 isolate was found to be more effective than the Pf 6 isolate.
In order to obtain plasma for determination sP-selectin, PF4, L-arginine, ADMA, and SDMA in the second part of the experiment, blood was collected in the Sarstedt S-Monovette (1.6 mg EDTA/ml blood) tube and within 30 minutes after the collection, it was centrifuged at 1000 xg for 15 min at 4[degrees]C and stored at -20[degrees]C until analysis.
The exact pathophysiology remains unclear but is thought to be due to the interaction of negative polyanions such as nucleic acids and lipopolysaccharides with PF4 [9, 10].
The activated platelets could result in forming platelet factor 4 (PF4), while the formed thrombin could couple with antithrombin III to generate thrombin-antithrombin III (TAT) complexes [31].
C-K O-K Al-K Si-K S-K Ti-K V-K Base(495)_pf1 1-2 0.00 0.0- 0.62 0.05 0.00 0.13 Base(49;)_pf2 1.26 0.00 0.04 0.54 0.00 0.00 0.12 Base(495) pf3 1.66 0.00 0.07 0.60 0.00 0.00 0.17 Base(495) pf4 1.64 0.00 0.04 0.56 0.05 0.00 0.09 Base(495) pt5 3.60 0.00 0.00 0.47 0.00 0.00 0.10 Base(495) pt6 1.53 0.00 0.06 0.58 0.02 0.00 0.08 Cr-K Mn-K Fe-K Ni-K Mo-L Base(495)_pf1 12.53 0.79 83.94 j 0.15 0.00 Base(49;)_pf2 11.49 1.33 84.-2 0.43 0.07 Base(495) pf3 11.85 0.65 84.69 i 0.22 0.09 Base(495) pf4 12.07 0.89 84.36 i 0.30 0.00 Base(495) pt5 11.68 0.84 82.77 i 0.46 0.08 Base(495) pt6 12.56 0.46 84.43 i 0.27 0.00 Fig.
Heparin binds to PF4, and the heparin-PF4 complex is immunogenic, which induces the expression of IgG, as well as IgA and IgM antibodies against the heparin-PF4 complex.
Item Loading SE [alpha] [rho] AVE Construct Anonymous communication AC1 .82 (***) .03 .79 .87 .62 AC2 .84 (***) .02 AC3 .72 (***) .05 AC4 .76 (***) .04 Perceived freedom PF1 .83 (***) .03 .85 .89 .63 PF2 .74 (***) .04 PF3 .83 (***) .03 PF4 .74 (***) .04 PF5 .82 (***) .03 Perceived need for legal protection LP1 .77 (***) .05 .72 .85 .64 LP2 .83 (***) .04 LP3 .80 (***) .04 Propensity to trust PT1 .75 (***) .15 .82 .88 .63 PT2 .85 (***) .17 PT3 .83 (***) .11 PT4 .75 (***) .13 Note: SE = standard error, [alpha] = Cronbach's alpha, [rho] = Dillon Goldstein's rho, AVE = average variance extracted.
Heparin-induced thrombocytopenia (HIT) is a serious complication from heparin use, arising from the binding of antibody against heparin-platelet factor 4 (PF4) complexes onto platelets.
The pathogenesis of HIT has been recently better defined: duringthe early phase heparin binds to platelet factor 4 (PF4), generating a complex (heparin-PF4) toward which IgG antibodies are produced and this complex is also able to activate platelets via FcyRIIa receptor, causing microthrombosis and thrombocytopenia.