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Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle.
Park et al., "AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPAR[alpha] and PGC-1," Biochemical and Biophysical Research Communications, vol.
For the first construct, N-terminal HA-tagged human PGC-1 [alpha] was cloned into an adenoviral vector that codes for CMV promoter-driven green fluorescent protein (GFP).
Arany, "PGC-1 coactivators in cardiac development and disease," Circulation Research, vol.
(2010) Nitric oxide and AMPK cooperatively regulate PGC-1 in skeletal muscle cells.
But mice genetically tweaked to produce more PGC-1 alpha 1 in their skeletal muscles seemed immune to chronic stress and showed fewer depressive signs, says study coauthor Maria Lindskog of the Karolinska Institutet in Stockholm.
An activation of mitochondrial biogenesis occurs through the coordinated expression of PGC-1 transcriptional co-activators, transcription factors, and nuclear receptors.
"We discovered that when we boost PGC-1 within the fly's digestive tract, the fly lives significantly longer.
Pasinetti and colleagues found that a gene known as proliferator-activated receptor coactivator 1 (PGC-1), a key regulator of glucose currently investigated as a potential therapeutic target for Type 2 diabetes, is decreased in Alzheimer's disease.
Barres and colleagues found that cells from people who have diabetes already have these changes, particularly in PGC-1, a gene that orchestrates burning fat.
De alli, que se han analizado genes candidatos y polimorfismos asociados a RI, entre ellos el polimorfismo Gly482Ser del gen coactivador- 1[alfa] del receptor activado de proliferacion de los peroxisomas [gamma] (PGC-1) (4, 5).
The PPAR[gamma] coactivator-1 (PGC-1) family is composed of PGC-1[alpha], PGC-1[beta], and PGC-1-related coactivator (PrC).
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