My objectives are (1) to determine the role of PGC-1
in mitochondrial metabolism during CD8+ TM development and (2) to investigate whether agents that promote MB enhance vaccine efficacy.
But mice genetically tweaked to produce more PGC-1
alpha 1 in their skeletal muscles seemed immune to chronic stress and showed fewer depressive signs, says study coauthor Maria Lindskog of the Karolinska Institutet in Stockholm.
We discovered that when we boost PGC-1
within the fly's digestive tract, the fly lives significantly longer.
Pasinetti and his colleagues are optimistic that if they find that PGC-1
can be manipulated pharmacologically to prevent BACE accumulation in the brain, these studies will provide important insights for the formulation of novel treatments and possible preventative strategies in Alzheimer's disease.
Numerosos estudios a nivel mundial han asociado el polimorfismo Gly482Ser del gen PGC-1
con alteraciones de la oxidacion de los acidos grasos, obesidad, resistencia a la insulina, alto riesgo para diabetes mellitus tipo 2 y enfermedades cardiovasculares (4, 7, 10-15).
Suppression of reactive oxygen species and neurodegeneration by the PGC-1
transcriptional coactivators," Cell, vol.
The researchers identified PGC-1
by sorting through genes that are active in brown fat.
As explained in the January 31, 2014, issue of Cell Metabolism, researchers in Boston discovered that high blood sugar levels prompt levels of a molecule called PGC-1
alpha to rise.
They report what happens when muscle tissue lacks PGC-1
, a protein coactivator that muscles need to convert fuel into energy.
Pasinetti and colleagues found that PGC-1
, a key regulator of glucose currently investigated as a potential therapeutic target for Type 2 diabetes, is decreased in Alzheimer's disease.
Before the researchers undertook this research, they had already found in a previous study that muscle cells from people with type II diabetes showed such telltale epigenetic alterations to their DNA, particularly in the PGC-1
gene, which orchestrates metabolic programmes critical to the burning of fat in mitochondria, the chambers in cells that generate energy.
decreased in Alzheimer' disease dementia cases with progression of the clinical disease and led to the accumulation of E--amyloid, an abnormal protein highly linked to Alzheimer' disease dementia and brain degeneration.