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Bristol-Myers Squibb will be solely responsible for the development, manufacturing and commercialization of ONO-4578 as well as other PGE2 receptor antagonist products in all countries of the world except Japan, South Korea, Taiwan, China and Association of Southeast Asian Nations (ASEAN) countries.
The terms of the agreement grant BMS the rights to develop and commercialise ONO-4578 and other compounds from PGE2 receptor antagonist programmes globally, excluding Japan, South Korea, Taiwan, China and Association of South-East Asian Nations (ASEAN) countries.
PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase a cascade.
PGE2 induces IL-6 in orbital fibroblasts through EP2 receptors and increased gene promoter activity: Implications to thyroid-associated ophthalmopathy.
Researchers discovered a role for PGE2 in muscle repair by noting that its receptor was expressed at higher levels on stem cells shortly after injury.
Conclusion: PGE2 showed significantly greater success in terms of vaginal delivery within 24 hrs as compared to Foley catheter in females presenting with postdates pregnancy.
Several studies have shown that COX-2 participates in the production of PGE2, which induces the tumor extension associated with the overexpression of this enzyme.
Group B = 72 subjects for early induction group with PROM less than 6 hours by intracervical PGE2 gel.
In a subsequent case-control study, Offenbacher and others measured levels of PGE2 and IL-1 in the gingival crevicular fluid (GCF) of 48 mothers of PTLBW infants.
Plant-based extracts, such as bromelain derived from Ananas comosus, effectively block PGE2 pathways specifically in glioblastoma tumors.
In M0, aqueous samples of CT group showed a significantly higher concentration of PGE2 in comparison with other groups (P<0.
Incomplete Na+ absorption in thick ascending loop of Henle results in raised level of PGE2 that further aggravates primary defect of Cl- transport in the thick ascending loop of Henle.
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