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The list of SDH-mutant tumors has slowly expanded in the past 17 years and now includes SDH-deficient PGLs, PCCs, RCCs, GISTs, pituitary adenomas (PAs), and less commonly, thyroid tumors and neuroblastomas.
found germline mutations in 28.7% of PGLs and 4.5% of PCCs.
(3,12,14,15) However, not only is it important for first-degree relatives of affected individuals to undergo genetic testing, but also patients presenting with apparently sporadic PCCs and PGLs, especially when exhibiting qualities of PGL4 such as having malignant multifocal or extra-adrenal tumors, or early-onset presentation.
Although the pathogenetic role of all these variants is still not known, due to the large number of susceptibility genes implicated in the diagnosis of inherited PCCs and PGLs, we confirm also what other authors stated that the next-generation sequencing technology is ideally suited for carrying out genetic screening of these individuals .
Patients are prone to a set of clinical features, occurring isolated or in different combinations: polycythemia since early childhood, PHEO, PGL, duodenal somatostatinomas, and retinopathy [50, 72-82].
For example, 18% of patients with thoraco-abdomen-pelvic PGLs have been reported to have a new tumor event within the first five years after initial surgical resection .
Bocquet, "THz power divider circuits on planar Goubau lines (PGLs)," Progress In Electromagnetics Research C, Vol.
DISCUSSION: Paragangliomas (PGLs) are extra-adrenally located in 10% of cases.
tuberculosis/ use PGLs to weaken our body defenses whereas /M.
Previous study identified the involvement of the gene pks 15/1 in the biosynthesis of PGLs; disruption of this gene generated a PGL-deficient mutant (8).
Paragangliomas (PGLs) of head and neck sites are uncommon, representing less than 1% of all tumors in the head and neck area, with most of these tumors arising in the carotid body or jugular bulb.
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