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Conivaptan increased PGRN levels, contrary to mannitol
In a recent partnership among several PGRN members, investigators found that 1 out of 4 pharmacogenomic test results had a potential clinically actionable outcome.
Up to now, the clinical data have revealed a relationship between PGRN levels and obesity.
En el 2006 se hallo que las mutaciones en la PGRN eran las responsables de la DFT en estas familias (32,60).
The Research Network page features a complete listing of PGRN scientists, with links to profiles of their projects.
from China (manuscript titled "Circulating PGRN Levels Are Increased but Not Associated with Insulin Sensitivity or p-Cell Function in Chinese Obese Children") investigated the association of progranulin with insulin sensitivity or [beta]-cell function in a Chinese paediatric cohort, (ii) N.
Progranulin (PGRN) is a secreted glycoprotein that was first isolated from a teratoma prostate cancer cell line [9-11].
One such effort, the Pharmacogenetics Research Network (PGRN), was established in 2000 and currently funds 13 academic research groups conducting basic research describing pharmacogenetic phenotypes and relating them to genetic and genomic information.
 To measure GCF and CP with T2DM patients serum levels of showed more hs-CRP and progranulin and hs-CRP PGRN levels than the in control subjects, CP other groups.
It is worth to mention the presence of an additional ligand capable of incorporating both TNF-R1 and TNF-R2 with still increasing importance in the pathogenesis of OA, which is progranulin (PGRN) also known as granulin epithelin precursor (GEP), PC-cell derived growth factor (PCDGF), proepithelin (PEPI), or acrogranin [77-80].
In addition, granulin-epithelin precursor (GEP, a newly identified chondrogenic growth factor, which was also known as proepithelin, acrogranin, progranulin (PGRN), and GP88/PC cell-derived growth factor) inhibited the action of ADAMTS-12 preventing COMP degradation via two distinct mechanisms [61, 92-97].
The widespread expression of PGRN gene makes it act in many physiological and pathophysiological processes, such as the inflammatory response, the injury-induced tissue repair, and the tumor formation progression [3, 4].
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