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The concentration used for PGSM ranged from 5ug/mL to 0.16ug/mL; for interferon-[alpha], the concentration used ranged from 80U/mL to 2.5U/mL; the concentration used for R7227 ranged from 2.5 ng/mL to 0.08ng/mL; and for BMS 790052, the concentration used ranged from 20 pg/mL to 0.63 pg/mL.
Huh7 cells harboring HCV subgenomic replicon (genotype 1b) were treated with either various concentrations of PGSM alone or in combination with IFN-[alpha], BMS790052 (NS5Ai), and VX-950 (PI), respectively.
The half maximal effective concentration ([EC.sub.50]) of PGSM to inhibit HCV replication was 35 [micro]g/mL.
We showed that all triterpenoid saponins, including PGSM, PD, P[D.sub.2], [PD.sub.3], DPD, [DPD.sub.2], and PA inhibited RdRp activity, and inhibition occurred in a dose-dependent manner with [IC.sub.50] value of 5 [micro]g/mL, 5 [micro]g/mL, 6 [micro]g/mL, 8 [micro]g/mL, 7 [micro]g/mL, 10 [micro]g/mL, and 15 [micro]g/mL, respectively (Table 1).
As shown in Table 2, PGSM and its subfractions of triterpenoid saponins inhibited HCV RNA replication in HCV replicon cells and in HCVcc-infected cells.
Synergistic Effect of PGSM on IFN-[alpha] and HCV Inhibitor-Mediated Antiviral Activity in HCV Replicon Cells.
PGSM Potentiates IFN-[alpha]-Mediated Anti-HCV Activity.
PGSM Potentiates Colony Suppression in Replicon Cells in Combination with Either IFN-[alpha] or DAAs.
'PGSM hopes this new change promises the best for Malaysia, by strengthening the judiciary and Islamic law,' he reportedly said.
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