A cost estimation workgroup was also convened by PHLF to recommend a methodology for estimating the resources required to fully implement FPHS using a relatively rapid and low-cost strategy that could generate estimates with an acceptable level of precision.
To determine the expected cost of full attainment for each FPHS domain, the conventional method would be to elicit direct estimates from health agency respondents on the fraction of resource use or expected resources required to achieve the desired level of attainment as defined in PHLF (2014).
Prior to filling out the survey questionnaire, respondents were requested to first read the FPHS Definitions Document from PHLF (2014), and then answer questions regarding resource use and allocation based on their understanding of each FPHS domain.
PHLF was diagnosed and graded (grade A, B, or C) according to the proposed definition by the International Study Group of Liver Surgery (ISGLS) .
Univariate and multivariate logistic regression analyses were performed to determine independent preoperative predictive factors of PHLF, major morbidity, and 30-day mortality.
PHLF was detected in 26.3% of patients, major complications (grade III-IV) in 26.8% of patients, and 30-day mortality in 11.3% of patients.
Furthermore, in the group with platelet count of <150 x [10.sup.9]/L PHLF, major complications and 30-day mortality were detected in 58.8%, 35.3%, and 35.3% of patients, respectively (Table 2).
To investigate the impact of the preoperative platelet count on postoperative outcomes including PHLF, morbidity, and 30-day mortality, we performed univariate and multivariate regression analysis.
After excluding patients with underlying cirrhosis (n = 7), we repeated univariate and multivariate analysis of PHLF, major morbidity and 30-day mortality.
(1) Only based on phrasal definition, every small for size remnant liver following EH can be considered as SFSS; however, it has to be distinguished between the proper model of SFSS and the irreversible acute PHLF.
Histopathological evaluation revealed massive necrosis, hemorrhage, congestion, and low mitoses in all animals in group C, indicating irreversible PHLF .