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PHLPPPH domain Leucine-rich repeat Protein Phosphatase
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Similarly, the overexpressed PTENP1, sequestering miR-17, miR-19b, and miR-20a, upregulated PTEN, PHLPP, and such autophagy genes as ATG7, ULK1, and p62, which in turn repressed the tumorigenic properties of HCC cells [10].
PHLPP. Akt activity can be inhibited by PH domain leucine-rich repeat protein phosphatase (PHLPP), a protein phosphatase 2C(PP2C) family member that selectively dephosphorylates Akt at Ser473.
Serine/threonine kinase akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPL.
McKnight Brain Institute found that a recently discovered enzyme, known as PHLPP (pronounced "flip"), might be silencing a vital cell-survival protein in the region where neurons are most susceptible to damage and death.