PI3K-AKTPhosphatidylinositol-3-Kinase and Protein Kinase B
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IGF-1 and LY294002 were known as the activator and inhibitor of PI3K-Akt signaling pathway.[16],[17] IGF-1 and LY294002 were separately utilized in rescue assays.
Liu et al., "Quantitative proteomics reveals that miR-155 regulates the PI3K-AKT pathway in diffuse large B-cell lymphoma," The American Journal of Pathology, vol.
Combined with Tables 4 and 5, it could be found that the signaling pathways associated with these module-related DEGs were described as follows: pathways in cancer (ID: hsa05200), PI3K-Akt signaling pathway (ID: hsa04151), focal adhesion (ID: hsa04510), transcriptional misregulation in cancer (ID: hsa05202), TNF signaling pathway (ID: hsa04668), Gap junction (ID: hsa04540), protein digestion and absorption (ID: hsa04974), and steroid biosynthesis (ID: hsa00100).
Previous studies have suggested that PI3K-Akt signaling pathway is implicated in the regulation of cell growth, proliferation, and survival [38].
In vitro and in vivo studies by Gu et al (28) have also shown that PR expression is regulated by PI3K-AKT pathway in endometrial cancer cells lines.
The cells were divided into four groups: a wild-type group (cell), a negative control group (NC; transfected with empty vector), an experimental group that was transfected with the FHIT overexpression plasmid (FHIT), and an LY294002 (PI3K-Akt signal pathway inhibitor) treatment group that was treated with 20 ^mol LY294002 for 48 h.
Now, researchers at Beth Israel Deaconess Medical Center (BIDMC) have identified the mechanism responsible for inhibition of AMPK activity in the hypothalamus, a discovery that not only provides a deeper understanding of energy balance but also reveals a critical integration point where multiple signaling pathways, including PI3K-AKT and mTOR converge.
Targeting the PI3K-Akt pathway in human cancer:rationale and promise.
Laerum, "Molecular analysis of the PI3K-AKT pathway in uterine cervical neoplasia: frequent PIK3CA amplification and AKT phosphorylation," International Journal of Cancer, vol.
Ji, "The Cardioprotective Effect of Icariin on Ischemia-Reperfusion Injury in Isolated Rat Heart: Potential Involvement of the PI3K-Akt Signaling Pathway," Cardiovascular Therapeutics, vol.
Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes.