In vitro and in vivo studies by Gu et al (28) have also shown that PR expression is regulated by PI3K-AKT
pathway in endometrial cancer cells lines.
, mTOR-p70S6 kinase and AMPK pathways play distinct and critical roles in metabolic regulation, and each pathway is necessary for leptin's anorexigenic effects in the hypothalamus, which inhibit food intake.
Two signaling pathways, RAS-MAPK and PI3K-AKT
, are involved in phosphorylation of MITF and lead to MITF protein degradation.
Cantley, "Cell-to-cell variability in PI3K protein level regulates PI3K-AKT
pathway activity in cell populations," Current Biology, vol.
reported that AMPK activation subsequently enhanced insulin sensitivity, thus leading to a progressively activated PI3K-AKT
pathway in differentiated 3T3 adipocytes (Tao et al.