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PIAS1Protein Inhibitor of Activated STAT (Signal Transducer and Activator of Transcription)1
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References in periodicals archive ?
Studies showed that PIASy cooperated with PIAS1 to regulate the specificity and magnitude of NF-[kappa]B-mediated gene activation [18].
Supporting this notion, a negative regulator of Treg development PIAS1 maintains the Foxp3 promoter in its methylated state by binding to it and recruiting DNA methyltransferases and Heterochromatin protein 1 resulting in the formation of a "repressive complex" [77].
Transcription factor Sp3 is silenced through SUMO modification by PIAS1. EMBO.