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PIAS1Protein Inhibitor of Activated STAT (Signal Transducer and Activator of Transcription)1
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Transcription factor Sp3 is silenced through SUMO modification by PIAS1.
It is now understood that ubiquitilation process plays important role in regulating DSB repair, and that perturbation of its control molecules including Small ubiquitin-related modifier (SUMO), E3 ligase (such as PIAS1 and PIAS4) may induce impaired DNA DSB repair [10].