PJIAPrincess Juliana International Airport
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Actemra can be given alone or in combination with methotrexate in patients with PJIA. In 2013, FDA approved the intravenous formulation of Actemra for patients two years of age and older with active PJIA.
The approval is based on data from the JIGSAW-117 study, a 52-week, open-label, multicenter, phase 1b pharmacokinetic /pharmacodynamic bridging study designed to determine the appropriate dosing regimen of Actemra SC across a range of body weights in children with PJIA.
Among them, 47 were diagnosed with oJIA (male/female: 11/36, mean age: 9.6 years, and range: 2.5-15.2), 11 with rheumatoid factor(RF-) negative pJIA (male/female: 4/7, mean age: 10.7 years, and range: 2.9-18.3), and 11 with sJIA (male/female: 7/4, mean age: 9.9 years, and range: 5.1-15.4), according to the International League Against Rheumatism criteria [24].
The report provides comprehensive information on the therapeutics under development for Polyarticular Juvenile Idiopathic Arthritis (PJIA), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.
Subjects and Methods: A total of 50 patients of PJIA coming to Rheumatology Outpatient Department were recruited in the study after informed consent.
He said that 25% of the 1.7 million annual passenger movements at PJIA were already transfers to surrounding islands such as Anguilla, St Barts, Tortola, Saba, Statia, St Kitts and Nevis, and that his company planned to raise that proportion to 30%.
Actemra is not approved for subcutaneous use in people with PJIA or SJIA.