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PKCAProtein kinase C alpha
PKCAPublic Key Cryptography Authentication
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In resting cells, inactive RIG-I is kept in a close conformation by PKCa. PKC[beta] and CK2 phosphorylate both CARDs and CTD.
We used this dose as previously performed in studies on the rapid actions of aldosterone on the protein levels of upstream/downstream mediators [12, 13], PKCa and [[alpha].sub.1]- [Na.sup.+]/[K.sup.+]-ATPase [11].
For example, for PKCA, the Sn, MCC, F1, and Pre values are 69.5%, 39.8%, 40.5%, and 28.6%, which are improved by 11.6%, 7.1%, 5.6%, and 3.6% compared with the method using local sequences only.
At different time points, the expression of claudin-5, occludin, ZO-1, and PKCa signaling pathway in microvessel fragments of cerebral ischemic tissue were evaluated.
TPA-induced membrane localization of PKCa was blocked by pretreatment with curcumin for 1 h (Fig.
Antineoplaston induces Gl arrest by PKCa and MAPK pathway in SKBT-3 breast cancer cells.
l-methyl-4-phenylpyridinium induces synaptic dysfunction through a pathway involving caspase and PKCa enzymatic activities.
Kroon et al., "MicroRNA 15a, inversely correlated to PKCa, is a potential marker to differentiate between benign and malignant renal tumors in biopsy and urine samples," The American Journal of Pathology, vol.
Diomede et al., "Nuclear translocation of PKCa isoenzyme is involved in neurogenic commitment of human neural crest-derived periodontal ligament stem cells," Cellular Signalling, vol.
Sun, "PKCa take part in CCR7/NF-[kappa]B autocrine signaling loop in CCR7-positive squamous cell carcinoma of head and neck," Molecular and Cellular Biochemistry, vol.
6-Gingerol significantly suppressed Ik[beta][alpha] phosphorylation, NF-k[beta] nuclear activation, and PKCa translocation which in turn inhibited [Ca.sup.2+] mobilization and disrupted mitochondrial membrane potential in LPS-stimulated macrophages.
Phosphorylation of Ser579 by Cdk1 [9, 44], Pkca [45], Erk1/2 [46, 47], or Cdk5 [48] induces mitochondrial fission.