Xiong et al., "Foetal nicotine exposure causes PKCe
gene repression by promoter methylation in rat hearts," Cardiovascular Research, vol.
We found using a novel PKCe
TG mouse model that the PKCe
levels in epidermis dictate the susceptibility of transgenic mice to the induction of SCC by UV .
transgenic epidermis after UV irradiation compared to controls.
It should, however, be noted that while many chemical constituents in the DG extract likely produce ROS through CYP-catalyzed biotransformation resulting in cytoprotection, it is also possible that components such as puerarin and diadzein can act directly by opening the [Ca.sup.2+]-activated potassium channel and activating PKCe
or inhibiting nuclear factor-kappa B activation, respectively (Gao et al., 2006; Kim et al., 2009).
Dorn II, "Combined cardiomyocyte PKCS and PKCe
gene deletion uncovers their central role in restraining developmental and reactive heart growth," Science Signaling, vol.
Zhang, "Hypoxia-derived oxidative stress mediates epigenetic repression of PKCe
gene in foetal rat hearts," Cardiovascular Research, vol.
This ciliary slowing is regulated by the activation of another signaling protein called protein kinase Ce (PKCe
); moreover, once PKCe
becomes inactivated again, the ciliated cells detach from the epithelium (Slager et al.
Studies demonstrated that in the IP protection cascade mito[K.sub.ATP] channel opening causes an increase in ROS production, which activates protein kinase C (PKCe
), which prolongs the phosphorylation-dependent open state of mito[K.sub.ATP] by forming a positive feedback loop .
Studies using the conventional knockout strategy found that global knockout of the gene encoding a brain enzyme called protein kinase C epsilon (PKCe
) reduced alcohol self-administration as well as signs of alcohol withdrawal (Hodge et al.
Zhang et al., "Nitric oxide (NO) induces nitration of protein kinase Ce (PKCe
), facilitating PKCe
translocation via enhanced PKCe-RACK2 interactions.
Molina et al., "PKCe
induces astrocyte stellation by modulating multiple cytoskeletal proteins and interacting with Rho a signalling pathways: implications for neuroinflammation," European Journal of Neuroscience, vol.