In previous research, Kanthasamy has shown that a novel protein-known as protein kinase-C (specifically PKCd) - kills essential dopamine-producing cells in the brain.
Signaling events leading to HLA-G inhibitory effects on malignant B cells were mediated through increased PKC[alpha]/[beta]II, PKCd, and PKCff phosphorylation and decreased phosphorylation of AKT, mTOR, GSK-3[beta], c-Raf, and Foxo proteins.