PKD1

Acronym	Definition
PKD1	Autosomal Dominant Polycystic Kidney Disease
PKD1	Polycystic Kidney Disease 1 Gene

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The polycystin complex (PKD1 and PKD2 encoding polycystin-1 and polycystin-2, respectively) is implicated in the regulation of the cell cycle and holds the key in the pathogenesis of ADPKD.

Autosomal Dominant Polycystic Kidney Disease and Pericardial Effusion

[7] Human genes: STRC, stereocilin; PMS2, PMS1 homolog 2, mismatch repair system component; PKD1, polycystin 1, transient receptor potential channel interacting; SMN1, survival of motor neuron 1, telomeric; CATSPER2, cation channel sperm associated 2; SMN1, survival of motor neuron 1, telomeric; SMN2, survival of motor neuron 2, centromeric.

Allele-Specific Droplet Digital PCR Combined with a Next-Generation Sequencing-Based Algorithm for Diagnostic Copy Number Analysis in Genes with High Homology: Proof of Concept Using Stereocilin

RAW264.7 cells were stimulated with 1 [micro]g/ml LPS (Escherichia coli O127:B8, Sigma-Aldrich) whereas 0.001, 0.1, 10, and 100 ng/ml PKD1 (129.3 kDa, Thermo Fisher Scientific, Denmark) were added apically to Caco-2 cells (Figure 1).

Administration of Protein Kinase D1 Induces a Protective Effect on Lipopolysaccharide-Induced Intestinal Inflammation in a Co-Culture Model of Intestinal Epithelial Caco-2 Cells and RAW264.7 Macrophage Cells

Phosphorylation by p38[delta] MAPK negatively regulates the activity of protein kinase D1 (PKD1), a known positive regulator of neuroendocrine cell secretion [72].

P38[delta] MAPK: emerging roles of a neglected isoform

For this reason, we use a selective PKD1 inhibitor, CID755376.

Sustained release of prostaglandin [E.sub.2] in fibroblasts expressing ectopically Cyclooxygenase 2 impairs P2Y-dependent [Ca.sup.2+]-mobilization

PKD1 and PKD2 genes that are mutated in Polycystic Kidney Disease (PKD) are likely to play a role in vessel biology and their dysfunction lead to aneurysm formation.

Genetics of Aneurysms in Few May Hint at Stroke Prevention for Many, Doc Says

Citation: "Reduced Ciliary Polycystin-2 in Induced Pluripotent Stem Cells from Polycystic Kidney Disease Patients with PKD1 Mutations"; Benjamin S.

Research findings point to new therapeutic approach for common cause of kidney failure

At least there are descriptions of 3 genetic variants of the disease;4 85% of cases (PKD1) are due to an abnormality at chromosome 16q13.3, while 15% (PKD2) are due to an abnormality at chromosome 4q21-23.

Autosomal dominant polycystic disease (ADPD)

Boletta et al., "PKD1 induces p21waf1 and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2," Cell, vol.

Analysis of the REJ module of polycystin-1 using molecular modeling and force-spectroscopy techniques