PLA2Phosolipase A2 (enzyme)
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PLA2 and proteolytic activities of BjuV were inhibited in vitro by BFRE at different ratios (1:1, 1:2, and 1:3, w/w) as shown in Figures 1 and 2, respectively.
PLA2 is extremely important in the inflammation cascade by catalyzing the conversion of membrane phospholipids in free arachidonic acid by hydrolysis [8,9], Then is converted by cyclooxygenases to prostaglandins and leukotrienes, increasing the inflammatory process [10].
A) Positions of the conserved helicase Walker A (GxxxxGKS), Walker B (EE), and replication initiator motifs (HuHuu and YuxK) in NS1 and of the phospholipase A2 (PLA2) and glycine-rich region (G-rich) in VP1 and VP2.
The cytotoxic mechanisms of 3FTXs, PLA2s, and SVMPs mainly involve the disruption of microvascular basement membranes [35] as well as endothelial cell membranes to result in the observed haemorrhage, oedema, and myonecrosis (resulting from disruption of plasma membranes of skeletal muscle cells) [32].
Xavier et al., "Snake Venom PLA2s Inhibitors Isolated from Brazilian Plants: Synthetic and Natural Molecules," BioMed Research International, vol.
The crotapotin (CA) and PLA2 were eluted from the column using a linear gradient of 2.0 M NaCl and 6.0 M urea buffered with Tris-HCl 50 mM, pH7.2.
The cold crystallization peak temperature of the extruded PLA ex, PLA4, and PLA2 are not significantly different.
PPAR[delta] activates PPRE-containing genes associated with metabolism (Olah, Ptgs2, Pla2, and Pld), invasion (Mmp12, Klk6), and inflammation (S100a8/9, Saa1/2/3).
PAP, PLA2, and p450 were highly expressed in HKI1532 (more than 10-fold) but much less in PC3.
Previous studies have shown that low-intensity LED could significantly reduce the mRNA expression of COX [28, 29], precursors such as phospholipase A2 (PLA2), and reactive oxygen species (ROS) [28].
His lab results were all normal (cholesterol, TG, HDL, LDL, FSH, LH, TSH, ACTH, vitamin A, free retinol, and plac Lp PLA2) except for human growth hormone, which was elevated (1.6ng/ml; normal range 0.01-0.97 ng/ml).
Phospholipase A2 (PLA2) is a major component of wasp venom [2, 8, 10].