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PLUNCPalate Lung and Nasal Epithelial Clone (gene)
PLUNCPlanning Land Use & Neighborhoods Committee (Seattle, WA)
References in periodicals archive ?
PLUNC is a secreted product of neutrophil granules.
Expression and clinical significance of PLUNC protein in nasal polyp and chronic sinusitis tissue.
Decreased PLUNC expression in nasal polyps is associated with multibacterial colonization in chronic rhinosinusitis patients.
Genomic organization of the mouse plunc gene and expression in the developing airways and thymus.
Cloning and expression of a mouse member of the PLUNC protein family exclusively expressed in tongue epithelium.
Next, we examined the correlation between clinical efficacy and the intensity of immunohistochemical positivity for PLUNC protein using the Spearman rank correlation analysis.
The most common levels of intensity of PLUNC protein expression were + in the nasal polyp samples, +++ in the chronic sinusitis samples, and ++ in the normal nasal mucosal tissue (figure, table 1).
Analysis of the Spearman rank correlation indicated that the intensity of PLUNC protein expression was significantly correlated with postoperative therapeutic efficacy (correlation coefficient = 0.
Using pH 4-7 gradient 2-DE, we found that the novel secretory protein PLUNC is differentially expressed among nasal polyps, chronic sinusitis, and normal nasal mucosal tissue.
Sung et al detected upregulation of PLUNC protein expression after bulbectomy in the respiratory epithelium and suggested that PLUNC protein may provide protection against infection after injury.
In our study, both proteomics and immunohistochemical analyses indicated that the highest levels of PLUNC protein expression occurred in chronic sinusitis and the lowest levels in nasal polyps.
8,9) These observations suggest that in response to irritation by infectious agents or chemical factors, the nasal mucosal epithelium, goblet cells, and glandular epithelium will proliferate reactively and produce anti-inflammatory agents, including PLUNC protein, as a defense against the irritant.