PLZFPromyelocytic Leukemia Zinc Finger
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Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein.
The obtained colonies of SSCs were immunocytochemically stained with anti- PLZF. Briefly, goat anti-PLZF (1:100, Santa Cruz Biotechnology, USA) was applied for 60 min at room temperature.
Peripheral DP T Cells Express Eomes and PLZF. To identify novel transcription factors involved in DP T cell development, we examined expression of Eomes and PLZF, which are expressed by T cells with innate immune properties [30].
Reverse transcription polymerase chain reaction (RT-PCR) was performed to assess the expression of spermatogonial cells genes, specifically OCT4, VASA, promyelocytic leukaemia zinc-finger (PLZF), and integrin a6 (INTGa6), during the entire culture.
Prive, "Crystal structure of the BTB domain from PLZF," Proceedings of the National Academy of Sciences of the United States of America, vol.
It expresses high amounts of PLZF, a transcription factor previously associated with NK-T cell development, and has the potential to differentiate in ILC1, ILC2, and ILC3 [19].
We also performed a nested polymerase chain reaction assay for several genes of interest, including CTLA-4, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, IL-17F, PLZF, Foxp3, RORyt, CD27, and CD70.
According to previous studies, co-expression of UCHL1 and promyelocyticleukaemia zinc finger protein PLZF in gonocytes and spermatogonia induced self-renewal and prevented differentiation (20).
The zinc finger and BTB domain containing 16 (Zbtb16) gene, described in humans since 1993, encodes for promyelocytic leukemia zinc finger protein (PLZF), a sequence-specific DNA-binding protein which bears a conserved N-terminal BTB/POZ repression and multimerization domain, a second region (RD2) responsible for transcriptional repression, and a C-terminal with nine C2H2 Kruppel-type zinc finger motifs that create the DNA-binding domain [1, 2].
"We found two new transcription factors - SRF and PLZF - involved in fat cell development.