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In most cases, the differential diagnosis is between PMLBCL, CHL, and other types of diffuse large B-cell lymphomas.
In comparing CHL and PMLBCL, Hoeller et al (72) suggest that expression of BOB1 favors PMLBCL and expression of cyclin E favors CHL.
As mentioned, there are considerable molecular similarities between PMLBCL and CHL, suggesting that lymphomas with overlapping features might exist.
However, it is impossible to make a diagnosis of PMLBCL without knowledge of the clinical picture because there is no pathognomonic histological feature.
The latter marker is important because sometimes there might be difficulty in differentiating PMLBCL from the grade II or syncitial variant of nodular sclerosing Hodgkin's disease which is usually CD45 negative.
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