In the United States, the MicroShunt (DE-128) is an investigational ab-externo, minimally-invasive surgical implant being studied for the treatment of primary open angle glaucoma (POAG
) in patients where intraocular pressure (IOP) is uncontrolled under maximum tolerated medical therapy or where the progression of disease warrants surgery.
The Glaucoma Research Foundation says that POAG
develops slowly and is the most common form of glaucoma and is caused by the slow clogging of the drainage canals that produces increased pressure on the eye.
is generally a disease of middle-aged and older adults, with one study estimating that 93% of cases occur in people 55 years of age and older.
In order to get answers to the questions posed in the study, we used statistical tests to compare the mean results recorded in the three groups of eyes (eyes with PEX syndrome and cataract; eyes with PEX glaucoma and cataract; and eyes with POAG
and cataract) for the study parameters (AL, ACD, K1, K2, AST, LT, CCT, RT, PD and WTW).
(21) evaluated the prevalence of depression in 41 PXG patients, 32 POAG
patients, and 40 control groups.
The diagnostic criteria of POAG
were defined in the 1987 Chinese expert consensus The Preliminary Proposals for Early Diagnosis of Primary Glaucoma as follows: 'POAG
can only be diagnosed with the condition that the anterior chamber angle is open and IOP is >21 mmHg (measured with Goldmann applanation tonometer) together with GON and/or glaucomatous visual field defects.' Furthermore, The Preliminary Proposals mentions that 'in the condition that GON and visual field defects occur without known reasons and IOP remains within normal limits, a diagnosis of NTG can be established.
A prospective follow-up study conducted from 1980 to 1986, respectively, to 1996, reported that neither current smokers nor exsmokers were at greater risk for POAG
than those who had never smoked and that heavy smokers were not at an increased risk of developing POAG
Corticosteroids are also alleged to cause glucocorticoid receptor-mediated cross linkage of actin-filament network21 and an expression of protein myocilin in trabecular meshwork impeding aqueous outflow.22 Patients with diabetic mellitus are more prone to have higher IOP and increased prevalence of POAG
and ocular hypertension.
During their four-day programme they will get to know each other, bond as a team, brain storm and formulate their ideas based on POAG
pillars - culture and heritage; educational and career; enhancing opportunity for less fortunate; environment and health and women leadership and family.
With respect to treatment in the secondary care setting, essentially this is the same for those patients with significant ocular hypertension (OHT) or proven POAG
. Topical drugs are used to reduce the IOP to a level where progression towards glaucoma is unlikely.
Maintenance of Intraocular Pressure (IOP) and its pathophysiology revolves around the aqueous dynamics,  and this is almost always the cause of Primary Open Angle Glaucoma (POAG
) and thus becoming the target for many medical and surgical therapies.
My struggle with this 'sight-stealing disease' started in 2011 when I was diagnosed with primary open-angle glaucoma (POAG