Penehyclidine hydrochloride administration during anesthesia may increase the incidence of POCD
in elderly patients in a dose-dependent manner (Mini-Mental State Examination [MMSE] score, 72 h after surgery).
The relationship between experiencing POD and POCD
and developing dementia in later life is becoming clearer.
is a major form of cognitive disturbance that can occur after anesthesia and surgery, but little is known about its potential risk factors.
In this study, we compared the influence of two different anesthetic and analgesic methods on POCD
of elderly patients who underwent non-cardiac surgery.
studies focused on cardiac surgery because, until recently, cognitive impairment after cardiac surgery was considered to result from physiological disturbances associated with the cardiopulmonary bypass technique.
This is a form of POCD
that can strike as much as 50% of older patients having heart surgery or hip replacement.
The good news is that the majority of patients with POCD
begin to improve within a month after leaving the hospital and return to their previous level of cognitive function within several months.
As far as POCD
is concerned, at present there is controversy as to whether it exists as a discrete entity, let alone whether anaesthesia has a part to play in its pathogenesis, or whether the choice of anaesthetic agent or technique influences its incidence.
The review found that the most common symptoms of POCD
are memory loss and lack of concentration, which are often--but not exclusively--associated with cardiac and hip-replacement surgery.
A previous study proposed that general anesthetics play a causal role in POCD
because the duration of anesthesia positively correlates with the incidence of POCD
Postoperative cognitive dysfunction, or POCD
, could be associated with dementia several years later.
The medical name for this type of memory loss is POCD
(postoperative cognitive dysfunction).