POEE was dissolved in DMSO to obtain a final concentration of 80 mg/ml in a DMSO 20% (v/v) solution.
1-42] and POEE doses used in the experiment did not affect locomotion ([F.
1-42] deposits are scarce in mice treated with POEE (Fig.
POEE 800 mg/kg (but not 300 mg/kg) significantly (p<0.
3A and B, 4A and B, and 5A and B show the effects of POEE (800 mg/kg) on AChE G1 and G4 activities in the hippocampus, frontal cortex and striatum, respectively.
6A and B shows the effects of POEE on the AChE immunocontent in synaptosomal membranes from the hippocampus and frontal cortex.
whereas POEE (50,100 and 300 mg/kg) and DMSO were given orally (p.
In order to check if POEE shows anxiolytic properties independent of previous stress, additional experiments were done after acute treatments.
To verify if POEE had an effect per se on glycemia, groups of mice (n = 8) were treated once with saline, imipramine 20 mg/kg (i.
1998, 2003), this study shows that an acute treatment with POEE can improve the protective defenses against oxidative stress in specific brain areas.
It is conceivable that POEE may contribute to the maintenance of neural membrane stability by inhibiting lipid peroxidation.
Data indicate that the highly active antioxidant compound(s) responsible for the high TAR levels observed with POEE experiments in vitro (Siqueira et al.