POT1


Also found in: Medical.
AcronymDefinition
POT1Protection of Telomeres 1 (protein)
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References in periodicals archive ?
Researchers revealed that the inactivation of POT1 caused by these mutations leads to longer and potentially unprotected telomeres, regions at the end of our chromosomes that protect chromosomes from damage.
According to the research team, there were also cases of other cancer types in families with these hereditary mutations such as leukaemias and brain tumours and the mutations that deactivate the POT1 gene may underlie other cancers, not just melanoma.
Proteins comprising the Shelterin complex are TRF1, TRF2, TIN2, RAP1, TPP1, and POT1. While each protein has been reported to participate in telomere synthesis and telomere protection, little is known about any potential role for them in AA.
Though low expression of POT1 was significantly associated with short telomeres (r = 0.398; P = 0.022*), there was no significant relationship between POT1 expression and [T.sub.H/S] (r = 0.168; P = 0.467).
In addition, the binding sites of GAPDH and other members of the shelterin complex, such as Pot1, are adjacent (35).
Structure of human pot1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection.
The studied genes included telomerase (TERT), telomerase-associated protein (TEP1), telomeric repeat binding factor 1 (TRF1), telomeric repeat binding factor 2 (TRF2) and protection of telomeres 1 (POT1).
By routing two matrix points, the Pot1 and Pot2 grounds in Figure 2, to the same pin on the DUT, the resistance measurement is very accurate because the remote sense location is at the DUT.
A command could, for instance, tell the internal processor to measure a voltage fed to the Pot1 Wiper input from the DAC.
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