Polymorphisms and expression of the chicken POU1F1
gene associated with carcass traits.
Lack of association of GH1 and POU1F1
gene variants with meat production traits in Piemontese cattle.
The significant influence of indels ofPOU1F1 and FSHb suggests that both POU1F1
and FSHb influence reproductive potential, and therefore, could be possible candidate genes for the breeding improvement of male piglets.
Localization of POU1F1
to bovine, ovine and caprine 1q21-22.
Here, we present 3 cases with POU1F1
mutation and 1 case with PROP1 mutation, who were molecularly diagnosed in Medical Genetics Department of Ege University.
is a tissue specific transcription factor that regulates gene expression, particularly in somatotrophs, lactotrophs, and thyrotrophs, which are responsible for growth related hormone secretion .
gene PCR amplified products were precipitated and sequenced on ABI 3100 DNA sequencer.
Pit-1 gene, POU1F1
, POU domain class 1 transcription factor 1 (Herr et al.
Several genes are known to affect meat quality through different roles in meat quality characteristics: the ryanodine receptor 1 (RYR1) , liver fatty acid-binding protein (L-FABP) , obesity-associated (FTO) gene , melanocortin receptor type 4 (MC4R) gene [5,6], POU1F1
[7-9], and protein kinase, AMP-activated and gamma 3 non-catalytic subunit (PRKAG3) [10 -12].
Because of the combination of central hypothyroidism, GH deficiency, low PRL status, and normal pituitary imaging, genetic testing of PROP1 and POU1F1
was performed, but no mutations were found.
One the other hand, the DNA methylation of Dnmt3b gene may regulate itself express, and different expression of Dnmt3b gene will directly or indirectly affect DNA methylation of other genes which may directly or indirectly influence growth traits in animal, such as GH, PRL, POU1F1
genes (Lan et al., 2007), IGFs and its binding protein genes.
To date, ATBF1 is described as the biggest anti-transcription factor for regulating expression of many critical genes, such as signal transducer and activator of transcription 3 (STAT3), pituitary specific transcription factor 1 (Pit1) (also known as POU1F1
) and prophet of Pit1 (PROP1) genes.