Interplay between statins and
PPARs in improving cardiovascular outcomes: a double edged sword?
Rifaai, "Peroxisome proliferator activator receptor (
PPAR)-[gamma] ligand, but not
PPAR-[alpha], ameliorates cyclophosphamide-induced oxidative stress and inflammation in rat liver,"
PPAR Research, vol.
The LBE treated cells showed a specific increase in expression of
PPAR target gene expression, including fatty acid binding protein 4, fatty acid transport protein 4, CD36 molecule, pyruvate dehydrogenase kinase 4, liver X receptor alpha and lipogenic stearoyl-CoA desaturase.
These results also provide a new rationale for developing therapeutics that could block
PPAR delta to treat inflammatory bowel disease and colorectal cancer," he said.
Pro-oxidant effect of dehydroepiandrosterone in rats is mediated by
PPAR activation.
We will focus on the premise that
PPAR activation is indeed anti-inflammatory and has therapeutic benefit.
In vitro
PPAR activity of nutmeg seeds was measured using a GAL4/
PPAR chimera & reported gene
These beneficial effects on glucose and lipids were observed without causing the weight gain which has been seen with other
PPAR agonists.
Activation of
PPAR gamma may mediate a portion of the anticancer activity of conjugated linoleic acid.
PPAR [gamma] geni Pro12Ala polimorfizminin diyabete karsi koruyucu olabilecegi ileri surulmus olmasina karsin, bu konuda farkli calismalardan celiskili sonuclar elde edilmistir.
The second drug candidate DB959 is a highly selective, non-thiazolidinedione (TZD), first-in-class dual
PPAR (peroxisome proliferator activated receptor) delta/gamma agonist in development for type II diabetes.
For example, GlaxoSmithKline Plc's diabetes drug Avandia, known generically as rosiglitazone, has been shown to restore gut defenses through
PPAR-gamma activation, he said, and Takeda Pharmaceutical's Actos, or pioglitazone, another
PPAR drug
