Peroxisome Proliferators-Activated Receptor (PPAR
) Modulators and Metabolic Disorders.
Res 2017:6139107, PMID: 29225614, https://doi.org/10.1155/2017/6139107.
Our findings as a whole imply that treatment with a dual PPAR
Galli, "PPAR[gamma] and oxidative stress: Con([beta]) catenating NRF2 and FOXO," PPAR
However, its expression as measured by mRNA levels is elevated in AD patients, suggesting that PPAR
may play a crucial role in modulating the pathology of AD .
Wong, "Current understanding of the role of PPARgamma in gastrointestinal cancers," PPAR
Considering the relevance of CD36 receptor to metabolism and accumulation of lipids in macrophages and previous reports demonstrating that this receptor is under transcriptional control of PPAR
family , we evaluated the participation of PPAR-[gamma] and PPAR-[beta]/[delta] in the upregulation of CD36 expression induced by MT-III.
Chawla, "Control of macrophage activation and function by PPARs
," Circulation Research, vol.
Effects of PPAR
? agonist pioglitazone on coronary atherosclerotic plaque composition and plaque progression in non diabetic patients: double centered randomized controlled VH-IVUS pilot trial.
In whole thiazolidinediones possess a large structure which enables them to bind to the polar as well as the big hydrophobic binding pockets of the ligand binding domain of PPAR
. The linker (L1) between the central phenyl ring and the thiazolidinedione is at its best if it has one carbon atom.
Robker, "Regulation of fatty acid oxidation in mouse cumulus-oocyte complexes during maturation and modulation by PPAR
agonists," PLoS One, vol.
Moreover, MDA (malondialdehyde) level, catalase activity, levels of insulin and PPAR
)' mRNA expression were also measured in pancreatic tissue.