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PPARAPeroxisome Proliferator-Activated Receptor-Alpha
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Microsomes and patients were genotyped for CYP3A5 rs776746 A>G (CYP3A5*3), CYP3A4 rs35599367 C>T (CYP3A4*22), POR rs1057868 C>T (POR*28), and PPARA rs4253728 G>A by use of Taqman[R] allelic discrimination assays on an ABI PRISM 7000 sequence detection system (Applied Biosystems).
05--indicated that ACSL1, ABCA1, DHCR24, ACAT2, ACACA, ABCG1, ACAD9, ACACB, IDI1, PPARG, SCD, SCARB1, HMGCS1, EBP, DHCR7, FASN, HMGCR, and GPAM were down-regulated upon G treatment; whereas NR1H2, PPARA, INSIG2, CPTP1, APOE, VLDLR, ABCC2, and SREBF2 were activated after exposure to G (Fig.