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PPARAPeroxisome Proliferator-Activated Receptor-Alpha
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DNA isolation and DNA methylation assay: To evaluate the promoter methylation status of PPARa PPAR and GR genomic DNA was extracted from liver tissue samples using a commercial Kit (TaKaRa Dalian China) according to the manufacturer's protocol.
Aerobic Exercise Modulates PPARa and PPAR[gamma] Gene and Protein Programs in the Liver.
[17] have found a similar result: miR-34a inhibition increases the levels of phosphorylated AMPK[alpha] separately through mediating PPARa regulation and SIRT1 pathway in hepatic steatosis mice.
Crabb, "Peroxisome proliferator-activated receptor [alpha] (PPAR[alpha]) agonist treatment reverses PPARa dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice," The Journal of Biological Chemistry, vol.
Scutellarin from Scutellaria baicalensis suppresses adipogenesis by upregulating PPARa in 3T3-L1 cells.
Leclercq, "Administration of the potent ppara agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice," Hepatology, vol.
A study on mice that were fed with high-fat diets following the oral administration of FC extracts at a dosage of 250 mg/kg/day for 7 days in vivo indicated that FC's lipidlowering action may be related to increased levels of liver PPARa [65].
AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARa and PGC-1.
No significant change was observed for AMPK (encoded by gene Prkaa1) and PPAR-[alpha] (encoded by gene Ppara) mRNA expression in TFL, TCL, and EC groups, compared with WC group.
[4] Human genes: APOE, apolipoprotein E; UCP2, uncoupling protein 2 (mitochondrial, proton carrier); LPL, lipoprotein lipase; APOA4, apolipoprotein A-IV; IL6, interleukin 6 (interferon [[beta].sub.2]); PECAMI platelet/ endothelial cell adhesion molecule (CD31 antigen); AGTRI, angiotensin II receptor, type 1; AGTR2, angiotensin II receptor, type 2; BDKRBI, bradykinin receptor B1; BDKRB2, bradykinin receptor B2; PPARA, peroxisome proliferator-activated receptor-[alpha]; F7, coagulation factor VII (serum prothrombin conversion accelerator); CETP, cholesteryl ester transfer protein.
Oleksiewicz, "PPARa and PPAR[gamma] are co-expressed, functional and show positive interactions in the rat urinary bladder urothelium," Journal of Applied Toxicology, vol.
Decreased levels of peroxisome proliferator-activated receptor alpha (PPARA) in chromosome 22 and lipid metabolism-related gene apolipoprotein E (APOE) in chromosome 19 have been identified confirming the findings that altered lipid metabolism may play a role in the progression of DPN [25].