As for the group of genes associated with chicken meat quality (Figure 4), a significant reduction of PDK4 and PPARD
transcript levels was observed in 6 h postmortem samples (p<0.05).
Association of PPARD
gene polymorphism with human physical performance.
Staiger et al., "Genetic variations in PPARD
and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention," The Journal of Clinical Endocrinology & Metabolism, vol.
Hiltunen et al., "Genetic study between SIRT1, PPARD
, PGC-1a genes and Alzheimer's disease," Journal of Neurology, vol.
According to DARA BioSciences Inc, DB959 is an oral, highly selective, dual nuclear receptor agonist whose primary target is PPARd
(peroxisome proliferator activated receptor delta).
Yang, "The role of PPARd
signaling in the cardiovascular system," Progress in Molecular Biology and Translational Science, vol.
The 15 chemicals with the third-highest average ToxPi scores ("Cluster 7") were characterized by activity on slices representing Other, PPARd
, and INSR, such as the pharmaceutical PharmaGSID_47315.
Is there an interaction between PPARD
T294C and PPARGC1A Gly482Ser polymorphisms and human endurance performance?
increases HDL synthesis through activation of ABCA1 gene (the cellular cholesterol exporter) .
Briefly, PPARA (CR456547_1), PPARD
(NM_006238.4), and PPARG (NM_015869.4) ORF sequences were synthesized, optimized for the expression in human cells, and cloned into the pDONR221 Entry Vectors (GeneArt, Thermo Fisher, USA).
Desvergne, "Integrative and systemic approaches for evaluating PPAR[beta]/[delta] (PPARD
) function," Nuclear Receptor Signaling, 2015.
On the contrary, an effect which was clearly independent of potential estrogenic properties of DBT was the pronounced downregulation of PPARd
mRNA expression by both doses of DBT (Figure 5(a)).