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PPARGPeroxisome Proliferator Activated Receptor Gamma
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References in periodicals archive ?
Different effects of PPARA, PPARG and ApoE SNPs on serum lipids in patients with coronary heart disease based on the presence of diabetes.
In the aforementioned study from China, the same variant was also found to interact with the PPARA rs1800206 C/G polymorphism as well as several PPARG polymorphisms.
The expression of adipogenic factors (CCAAT/enhancer binding protein beta, CCAAT/enhancer binding protein alpha, and PPARG) in the subcutaneous fat and IMF was higher in the high-concentrate group than that in the low-concentrate group, indicating that the dietary roughage/concentrate ratio affects adipogenic gene expression in fat tissues.
After the treatment with a combination of FA and gemcitabine, significant increases in the expression of CASP3, CASP7, CASP8, FAS, CYCS, TNF and PPARG were observed as 13.55, 9.48, 23.83, 51.63, 10.34, 17.86 and 14.63 folds, respectively compared with the control group (p<0.05).
A slightly higher level of p53 induced PPARG and reactive oxygen species, which led the cells to differentiate into fat cells, but not bone.
Bioinformatic analysis allowed us identifying a binding site at SNP rs9332978 for transcription factor PPARG as a potent coregulator of CYP4A11 gene expression (Table 6).
BSCL2 mRNA interference during that phase caused lower PPARG gene expression and adipogenesis impairment.
(c) apoA-I and apoE are mentioned above; ABCA1 and ABCG1 play a role in HDL metabolism; apoB is a major protein component of chylomicrons, VLDL, and LDL; PPARG is a nuclear receptor that controls the peroxisomal beta-oxidation pathway of fatty acids and regulates adipocyte differentiation and glucose homeostasis; PDZK1 is a PDZ domain containing scaffolding protein; THBS1 is a thrombospondin-1, adhesive glycoprotein, that mediates cell-to-cell and cell-to-matrix interactions, binds heparin.
Relative expression of three differentially expressed genes indicated by RNA-Seq and known to be regulated by estrogens, PPARG, SOCS3, and IL6R, was measured in this preliminary study.
According to the company, the 17 fusions include ALK, AXL, BRAF, CCND1, FGFR1, FGFR2, FGFR3, MET, NGR1, NTRK1, NTRK2, NTRK3, PPARG, RAF1, RET, ROS1 as well as THADA.
Co-administration of peroxisome proliferator-activated receptor-gamma (PPARg) antagonist significantly reduced this effect indicating that candesartan's neuroprotective effect occurs through AT1-receptor blocking and PPAR[gamma] activation (35).
Mutations in peroxisome proliferator activated receptor gamma (PPARG), which encodes a key transcription factor regulating adipocyte differentiation and insulin sensitivity, are also relatively common in FPLD patients (12).