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The aim of the present study was to test the impact of common genetic variations in ADIPOQ, RARRES2, and PPARGC1 on obesity-related traits and susceptibility in a sample of adult subjects from Rio de Janeiro, Brazil.
Genotypes for ADIPOQ (rs17366568 and rs182052), RARRES2 (rs17173608 and rs4721), and PPARGC1 (rs8192678 and rs3736265) variants were determined using real-time polymerase chain reaction TaqMan[R] assays (ThermoFisher, Carlsbad, CA, USA).
We did not find associations between SNPs in RARRES2 and PPARGC1 and obesity.
The PPARGC1 rs8192678 allele A presented higher triacylglycerol (P = 0.005) concentrations than G homozygous alleles.
Although we did not find any association between the five SNPs and adiposity, other risk phenotypes related to obesity were associated with LEPR rs1137101, POMC rs28932472, IGF2 rs680, PPARG rs1801282, and PPARGC1 rs8192678.
We also observed an association between PPARGC1 rs8192678 and higher triacylglycerol concentration in adolescents, which is similar to the results of an adult study (34).
Microarray analysis of gene expression relative to insulin signaling pathway in the LM in pigs (1) Gene (2) Symbol Gene ID p-value Phosphoinositide-3-kinase catalytic gamma polypeptide PIK3CG 396979 0.02400 Protein kinase, cAMP-dependent, regulatory, type II PRKAR2A 397493 0.00374 AMP-activated protein kinase alpha 2 AMPKA2 397504 0.01671 Peroxisome proliferator activated receptor,gamma,coactivator 1 PPARGC1 397013 0.03581 Protein phosphatase 1 catalytic subunit beta isoform PPP1CB 397378 0.02712 (1) There were used for analyses 6pigs per diet groups.
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- PPAR gamma
- PPAR Mouse
- PPAR-interacting protein
- PPARG angiopoietin-related protein