The ability to identify follicular thyroid tumors that produce PPFP is important for several reasons.
describe and validate a clinically applicable reverse-transcription PCR (RT-PCR)-based assay for the detection of PPFP in formalin-fixed/ paraffin-embedded tissues, fresh frozen tissues, and, potentially, fine-needle biopsy samples (7).
The fact that IHC detection of high PPAR[gamma] production was sensitive but not specific for PPFP detection replicates published data (5, 9).
Therefore, a very large number of samples will need to be studied to determine the utility of this (or any) assay for PPFP in a biopsy setting.
found PPFP to be present in 62% (13 of 21) of follicular carcinomas.
The passage of time and additional studies will reveal the optimal way(s) to detect PPFP in thyroid tumors and will define when this assay should be performed.