My initial assumption is that using PPIs
might be a trade-off.
Weighing the relief you could get by taking PPIs
and its potential side effects, what can you do for your heartburn?
block acid production; they are the most commonly prescribed drugs for GERD.
Negligence of prescribing PPIs
for patients in the high-risk group for NSAIDs-related GI bleeding is on one hand, whereas the inappropriate use of PPIs
is on the other (1-4).
over many months or years is not safe, and now we have a clearer picture of the health conditions associated with long-term PPI
use," said Ziyad Al-Aly, study's senior author.
In a shocking finding, individuals' PPI
use was associated with an 80% increased risk of liver cancer, compared with people who did not use PPIs
Understanding the role PPIs
and other medications play in managing upper GI conditions is essential to promote appropriate use of these drugs.
Jan Zirk-Sadowski, Ph.D., from the University of Exeter in the United Kingdom, and colleagues assessed associations between long-term use of PPIs
and pneumonia incidence.
Many studies also revealed PPIs
as a causative factor for atrial fibrillation.
Children who were prescribed more than 60 days of PPIs
had a 52% higher risk than did those who were prescribed 1-60 days, and a similar but slightly lower increased risk was seen in those prescribed more than 60 days of [H.sub.2]RAs (hazard ratio, 1.32).
Researchers saw a 25 percent higher risk of death in the 275,977 participants treated with PPIs
, compared with those who were treated with H2 receptors antagonists (95 percent confidence interval, 1.23-1.28) after adjusting for factors such as estimated glomerular filtration rate, age, hospitalizations, and a range of comorbidities, including gastrointestinal disorders.
However, customers who have balances in such wallets or prepaid payment instruments (PPIs
) need not worry about their money even if they do have not done the KYC (know-your- customer) norms.