PPNADPrimary Pigmented Nodular Adrenocortical Disease
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Adrenal pathology was also consistent with PPNAD, which indicated adrenocortical nodular hyperplasia, partly consist of transparent cytoplasm cells, partly by the abundant cytoplasm eosinophilic cells, with visible pigment in the cell.{Figure 1}
To date, a total of 117 different PRKAR1A mutations have been identified (see PRKAR1A Mutation Database) in 387 unrelated families of diverse ethnic origin; they are summarized by Horvath.[3] Treatment of PPNAD and CNC is the treatment of manifestations.
Primary pigmented adrenocortical nodular disease (PPNAD; MIM 610489) is a dominantly inherited genetic disorder with the majority of cases associated with Carney Complex type 1 (CNC1; MIM 160980).