Note: cAMP: Cyclic adenosine monophosphate; hCG, human chorionic gonadotropin; MAPK, mitogen-activated protein kinases; MEHP, mono(2-ethylhexyl) phthalate; PPAR[gamma], peroxisome proliferator-activated receptor gamma; PPRE
, peroxisome proliferator response element; PTGS2, prostaglandin-endoperoxide synthase 2; ROS, reactive oxygen species.
PPAR[gamma] transcriptionally regulates LRP1 gene due to the presence of PPRE
on the LRP1 promoter region .
Furthermore, bezafibrate also downregulates PPARD and TNF[alpha] expression, while upregulating FABP4  and adiponectin expression (partially through PPARa, enhancing the PPRE
site located in adiponectin promoter) in adipocytes [130, 131].
PPAR[gamma] exhibits a selective binding with half-site AGGTCA, of the PPRE
which make the DNA binding domain of the PPAR[gamma] polar .
Previous studies have reported that PPAR[gamma], whose ligand-binding domain is bound by the ligand, forms a dimer with RXR, which is a 9-cis-retinoic acid receptor, and thus that it controls adipocyte differentiation by combining with the peroxisome proliferator response element (PPRE
), which belongs to the area of the cis-acting element relevant to adipocyte differentiation (Kodera et al., 2000; Christine et al., 2005; Shanika et al., 2009).
When we used the human adiponectin promoter bearing the mutated PPAR response element [p(-908)/LUC PPRE
mut] there were no appreciable changes in luciferase activity indicating a possible major role for PPAR-[gamma] in the activation of adiponectin promoter (Fig.
However, the negative regulation of FSP27/CIDEC by fenofibrate may be indirect as the PPAR[alpha] agonist Wy-14643 did not activate the functional peroxisome proliferator-activated receptor response element (PPRE
) in the mouse fsp27 promoter in HEK293 cells .
Esophageal mucosal integrity was "severely impaired" in patients with confirmed EoE and in those with proton pump inhibitor--responsive eosinophilia (PPRE
), the researchers reported (Clin.
Les resultats de l'essai Fem-PPrE ont egalement ete decevants: l'etude a revele que la prophylaxie de la pre-exposition par voie orale (PPrE
) qui a tres bien fonctionne chez les HSH semblait inefficace pour les femmes heterosexuelles.
After the linear independent check of the screws to remain a three kinematic chain [(RRRE).sub.[parallel]], [(PRRE).sub.[parallel]], [(PPRE
where [p.sub.obs] is the observed precipitation rate, ppre
is the simulated flow rate, and p is the average value of the observed flowrate [3, 8].
The DNA binding domain (DBD) or C domain promotes the binding of PPAR to the peroxisome proliferation response element (PPRE
) in the promoter region of target genes .