The molecular epidemiology of PPRV
, which is based on sequence comparison of a small region of the fusion (F) gene (322 nt) or the nucleoprotein (N) gene (255 nt), has identified 4 distinct lineages (I-IV) of PPRV
Upon closing of the transaction, United Therapeutics will receive $350 million in cash in exchange for the PPRV
has been identified across much of the developing world; genetic analyses has grouped viruses into 4 lineages that were originally thought to be phylogeographically restricted (6).
To qualify to receive a PPRV
, a sponsor must submit an application for a drug or biologic intended to prevent or treat a rare pediatric disease.
Genetic analysis showed that PPRV
strains isolated in Morocco and Algeria belonged to lineage IV (4-6).
A seroprevalence survey was implemented in October 2010 to assess PPRV
spatial distribution in Mauritania.
However, critical questions remain about the role that species other than sheep and goats may play in PPRV
persistence (2,3,12); the value of serosurveillance in control efforts; and, more specifically, whether cattle and wildlife species are useful indicators of virus circulation.
We performed phylogenetic analysis of a 255-nt sequence of PPRV
NP gene, using a selection of reference strains: 7 new sequences from this study (GenBank accession nos.
is endemic to most of western Africa, and considered a major constraint on the livestock industry.
Although rinderpest virus was eradicated after intensive vaccination campaigns in the last quarter of the 20th century (6), PPRV
has continued to spread in Africa and Asia.
infection was officially reported in the Ngari region of western Tibet, People's Republic of China, in July 2007.
Infection with PPRV
results in an acute, highly contagious disease characterized by fever, anorexia, necrotic stomatitis, diarrhea, purulent ocular and nasal discharges, and respiratory distress (9,10).