PRC1Polycomb Repressive Complex 1
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Measure Staff Survey Qualitative Inquiry Survey Response by PRC, % (n) PRC1 18.
Keeping cell identity in Arabidopsis requires PRC1 RING-finger homologs that catalyze H2A monoubiquitination.
In short, SUMO helps the PRC1 complex repress genes, and SENP2 reverses this repression, allowing gene transcription and expression.
PRC1 acts by mediating the ubiquitination of the 119th lysine residue of histone H2A; this is achieved by two of the PRC1 proteins called ring finger protein 1A and 1B (RING1A and RING1B) (Wang et al.
PRC2 has similar repressive properties to PRC1 and also is an essential regulator of cellular differentiation.