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PRDI-BF1Positive Regulatory Domain I-Binding Factor 1
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Background: As a novel molecular markerof non-small cell lung cancer (NSCLC), PRDI-BF1 and RIZ homology domain containing protein 14 (PRDM14) is over-expressed in NSCLC tumor tissues.
The positive regulatory domain I-binding factor 1 and retinoblastoma protein-interacting zinc finger gene homology domain containing (PRDI-BF1 and RIZ homology domain containing, PRDM) family is a novel transcription regulator containing a N-terminal positive regulatory domain, followed by six deoxyribonucleic acid (DNA)-binding C2H2 zinc finger domains involved in human tumorigenesis.