PRG4Proteoglycan 4
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Se ha observado que el AH tambien podria sobrerregular la expresion de PRG4 en sinoviocitos de ATM osteoartriticas dentro de las 24 h in vitro, lo que sugiere que el efecto lubricante del AH exogeno podria estar asociado con la regulacion positiva de PRG4 (Guo et al.).
Moleculas lubricantes AH, PRG4, SZP, lubricina, mucinas.
Crystallinity degree (%) Sample PRG4 PRG5 PE 35 35 3% 44 43 5% 44 44 10% 41 43 TABLE 2.
A finance manager does not have any power in this hospital" (PRG4).
Currently, we describe that using a modification of the [beta]2GPI isolation procedure, the 1st elution peaks after cationic exchange chromatography, yielded a newly detected protein identified by LC-ESI-MS/MS as PRG4. This is a highly glycosylated human protein consisting of 1404 amino acids with a core molecular weight of ~150 kDA, ranging up to 400 kDa, depending on the O-glycosylation and glycosaminoglycan substitutions [27].
Schmidt, "Molecular weight characterization of PRG4 proteins using multi-angle laser light scattering (MALLS)," Osteoarthritis Cartilage, vol.
ADSC pellets cotreated with these two growth factors displayed increased GAG accumulation, improved histologic appearance with intense Alcian blue and Sirius red staining signal, and increased transcription of cartilage-related genes, such as aggrecan, Sox-9, Col2a1, and Prg4. Previously, some results also showed that insulin-like growth factor 1 (IGF-1) enhanced the chondrogenesis effects of TGF-[beta]1 and the combined application of TGF-[beta]3 and BMP-2 has a synergistic effect on chondrogenic differentiation [23, 25].
Chondrocytic-related genes of Col2a1 (a), Aggrecan (b), SOX9 (c), Prg4 (d), COMP (e), and Col10 (f) were quantified by real-time PCR in ADSC pellet, which were stimulated with TGF-[beta]3 alone, FGF-18 alone, and their combination for 5 weeks.
COL2A1 and PRG4 expression also showed a similar pattern as shown in Figure 4 (Figures 5(e) and 5(f)).
Lubricin, or PRG4, is a protein in the cartilage ECM and synovial fluid that participates in the lubrication of the joint articular cartilage [48].
Lassar, "Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways," Genes & Development, vol.
The expression of matrix proteins, (d) aggrecan (ACAN), (e) collagen type II (COL2A1), and lubricin (PRG4) was confirmed.