PRKACBProtein Kinase, cAMP (Adenosine 3'5' Cyclic Monophosphate)-Dependent, Catalytic, Beta
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Tian, "PRKACB is Downregulated in non-small cell lung cancer and exogenous PRKACB inhibits proliferation and invasion of LTEP-A2 cells," Oncology Letters, vol.
Wang and his group have demonstrated that the HULC lncRNA acts as ceRNA of the protein coding gene PRKACB and induces its increased translation by controlling the activity of miR-372.
For example, HULC is an lncRNA that is specifically overexpressed in hepatocellular carcinoma (HCC) [34] and functions as a miRNA sponge to restrain the activity of many miRNAs, such as hsa-miR-372-5p, leading to the suppression of its target gene PRKACB. Specifically, HULC acts as the catalytic subunit of PKA, induces the phosphorylation of cAMP response element binding protein (CREB), and promotes CREB-dependent HULC upregulation in HCC [35].