53 A recent trial has shown that use of PRRT
leads to an increase in progression-free survival.
treatment was approved earlier this year by the U.S.
: Peptide receptor radionuclide therapy is the administration of a radiopharmaceutical consisting of a beta emitting radionuclide chelated to a peptide.
[sup.68]Ga-DOTATATE and [sup.18]F-FDG were complementary in detecting lesions and dual-trace PET/CT showed an advantage in the assessment of SSA, PRRT
, and chemotherapy.
In cases with advanced disease, cytoablative procedures such as locoregional therapy and PRRT
may represent effective palliative therapeutic options .
Dr Diane Kraal from Monash University has warned flaws in the PRRT
regime mean Chevron's giant Gorgon gas project off WA will not pay the tax until "at least 2030", despite decades of operation.
Three of the 6 patients who had R2 resection received first-line treatment with SSAs, while 3 patients had PRRT
followed by SSA; finally, 3 patients already had metastases at diagnosis and had PRRT
followed by SSA as first-line therapy.
Currently available therapeutic options for patients with NETs can be summarized and subdivided into four major categories: (1) locoregional therapeutic options, including surgical resection or liver-directed therapies such as radiofrequency ablation (RFA), transcatheter arterial hepatic embolization (TAE), transcatheter arterial hepatic chemoembolization (TACE), or radioembolization therapy (TARE), (2) somatostatin receptor targeting therapeutic options, including somatostatin analogs and peptide receptor radionuclide therapy (PRRT
), and tryptophan hydroxylase inhibitors, (3) molecular and mutation targeting therapy, and (4) systemic chemotherapy.
It was therefore decided to perform a peptide radioreceptor radionuclide therapy (PRRT
) in 2013.
A number of therapeutic options are available for the medical management of GEP-NENs that are not amenable to surgery or they have developed disease progression including long acting SS-analogs, interferon a, conventional chemotherapy, molecular targeted agents, and treatment with radiopharmaceuticals known as peptide receptor radionuclide therapy (PRRT
) (Figures 1 and 2) .
Treatment modalities include surgical removal of tumor, somatostatin analogs and peptide receptor radionuclide therapy (PRRT
) [5, 7].