CAMs such as PSA-NCAM and SYNCAM, as well as several neurexins and neuroligins, differentially affect synaptic functions demonstrated by alterations in NMDA and AMPA receptor-mediated currents, as well as the expression of synaptic protein-mediated aspects of excitatory and inhibitory neurotransmission.
Skibo et al., "PSA-NCAM is required for activity-induced synaptic plasticity," Neuron, vol.
Wedzony, "Cocaine decreases the expression of PSA-NCAM protein and attenuates long-term potentiation via glucocorticoid receptors in the rat dentate gyrus," The European Journal of Neuroscience, vol.
Taylor, "Low prefrontal PSA-NCAM confers risk for alcoholism-related behavior," Nature Neuroscience, vol.
Cell adhesion molecule Abbreviation Neural cell adhesion molecule NCAM Polysialated neural cell adhesion molecule PSA-NCAM Neuronal cell adhesion molecule NRCAM Immunoglobulin super family IGSF Synaptic cell adhesion molecule SYNCAM Intercellular adhesion molecule 5 ICAM5 Cadherin 13 CDH13 Neurexin 3 NRXN3 Neurexin 2[beta] NRXN2[beta] Neuroligin 3 NLGN3 Neuroligan 1 NLGN1 Neurexin 3[beta] NRXN3[beta] Protein tyrosine phosphatase receptor D PTPRD Protein tyrosine phosphatase receptor B PTPRB CUB and Sushi multiple domains 1 CSMD1 Protein tyrosine phosphatase receptor Z 1 PTPRZ1 Table 2: Gene expression changes after repeated cocaine treatment.
Expression of PSA-NCAM in the Glomerular Layer, Granular Cell Layer, and Olfactory Tract.
Interestingly, the expression of the immature neuronal marker PSA-NCAM was significantly increased in the glomerular layer in PDD/DLB and FTLD only.
We also detected an increased number of cells expressing the immature neuronal marker PSA-NCAM in the glomerular layer of PDD/DLB and FTLD cases, though we were not able to detect DCX expressing cells in the OB regions analyzed.
Taken together, neurogenic and non-neurogenic regions of the human OB from AD, PDD/DLB, and FTLD patients contain PSA-NCAM expressing cells without further signs for the generation of new adult neurons.
Castillo-Gomez, "Structural plasticity of interneurons in the adult brain: role of PSA-NCAM and implications for psychiatric disorders," Neurochemical Research, vol.