As a subset, of the four patients that demonstrated disease progression at 31 weeks, 3 did not have an increase in their PSADT
For the ADT modelling,  used the nonlinear Wiener Process to model PSADT
, and  used the nonlinear Wiener Process to optimize sample size allocation for ADT.
In cases which demonstrate short PSADT
and SV invasion, the chances of microscopic metastasis and systemic relapse are higher and therefore the appropriate option would be to combine RT with HT.32
Postulating an exponential rather than linear PSA increase and a PSADT
of <12 months in these men presenting with PSA>100 at the age of 50 years, it is clear that to detect cancer at a potentially curable stage (PSA <20 ng/ml) would have required PSA testing at the age of 40, or even earlier.
show that PSADT
exhibits the behavior of surface erosion
Methods/Outcome Measures: Serial PSA measurement before study entry determined at baseline PSADT
was a good indicator of subsequent poor clinical outcomes, including cancer developing in other parts of the body or death related to prostate cancer.
PSA measurements were recorded and PSADT
In addition to immune responses, clinical correlative analyses evaluating PSA kinetics showed that patients with specific CD8+ T cell responses experienced dampening in the rise of PSA and significant increases in PSADT
. Additional prostate cancer tissue analyses are ongoing to further investigate immunological correlation.
BACKGROUND: Pomegranate juice has been associated with PSA doubling time (PSADT
) elongation in a single-arm phase II trial.
The following parameters were recorded: postoperative PSA (nadir), subsequent PSA doubling time (PSADT
), date of referral to our radio-oncology department, last PSA count before RT, date of first RT, whether prophylactic radiation to the pelvis and/or concomitant hormone therapy were given.
Randomization will be stratified by PSA doubling time (PSADT