PTBEPeninsula Temple Beth El (San Mateo, CA)
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The extent of peritumoral brain edema (PTBE) is one of the important prognostic factors in patients with meningioma.
* Most studies have reported that the extent of PTBE can be a reason for the poor outcome of surgical resection of meningiomas.
The relationship between tumor and PTBE was analyzed using edema index (EI).
In this study, we compared pial/cortical invasion, dural invasion, venous sinus invasion, bone infiltration and postoperative PTBE. The presence of postoperative PTBE was associated with cortical/pial invasion ([chi square]=15.74; p=3.84), dural invasion ([chi square]=9.06; p=3.84) and bone infiltration ([chi square]=9.33; p=3.84), but not with venous sinus invasion ([chi square]=0.86; p=3.84).
Some studies found no statistically significant correlation between tumor volume and PTBE (10,11), but some papers report on strong correlation between tumor volume and PTBE (6,8).
Many studies showed correlation between irregular tumor margins and significant PTBE (13-15).
Some studies showed that meningiomas with higher PTBE, irregular margins and invasive behavior were associated with higher Simpson grade (6,23).
Numerous studies showed association between Ki67 LI and PTBE, as well as between Ki67 LI and invasive behavior of meningiomas.
In this study, we analyzed the presence PTBE two to three months after surgical resection.
Our research showed tumor volume, margins, intraoperative signs of arachnoidal and pial invasion to be associated with PTBE in intracranial meningiomas.