PTEN


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Related to PTEN: p53, AKT, PI3K
AcronymDefinition
PTENPhosphatase and Tensin Homolog
PTENProtein Tyrosine Phosphatase
PTENPrime Time Entertainment Network (television network)
PTENPiedmont Triad Entrepreneurial Network (Greensboro, NC)
PTENProfessional Tool and Equipment News (magazine; Fort Atkinson, WI)
References in periodicals archive ?
Lack of PTEN expression in endometrial intraepithelial neoplasia is correlated with cancer progression.
The membranes were probed against PTEN (Santa Cruz, USA), or cleaved caspase-3 (Cell Signaling Technology, USA), and reprobed against GAPDH (Santa Cruz) as a loading control.
U6 and [beta]- actin were used as internal controls for miR-21 and PTEN mRNA quantitation, respectively.
The PTEN expression score was calculated as the product of the staining intensity and the percentage of positive tumor cells.
DNA ANALYSIS FOR PTEN AND STK11 MUTATIONS BY MULTIPLEX LIGATION-DEPENDENT PROBE AMPLIFICATION
Previous studies had linked mutations in PTEN with the unchecked growth of cancer cells.
Whites were more likely to have the PTEN mutation (17 of 78 patients, or 22%), compared with African Americans (3 of 62 patients, or 5%), said the study's lead investigator, Dr.
The researchers stained the samples for PTEN expression and linked that data with disease-free survival.
In this study, we demonstrated that PTEN downregulation and resultant activation of PI3K signaling caused PKC[zeta] activation, which in turn increased ROS production through NADPH oxidase expression and its activity modulation in replicative aged human dermal fibroblasts (HDFs).
The E3 ubiquitin ligase neural precursor cell expressed developmentally down-regulated 4-1 (NEDD4-1) negatively regulates PTEN protein stability through polyubiquitination.
PTEN gene mutations defined in approximately 60% of the patients and the disorder is classified as one of the PTEN Hamartomatous Tumor Syndromes.