PTLBWPreterm and Low Birth Weight
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In a subsequent case-control study, Offenbacher and others measured levels of PGE2 and IL-1 in the gingival crevicular fluid (GCF) of 48 mothers of PTLBW infants.
Of the PTLBW samples, 33.3% tested positive for IgM against the test bacteria, whereas only 17.9% of the normal birth weight samples tested positive.
Numerous studies show the prevalence and relationship between periodontal disease and PTLBW. Jeffcoat MKet al studied patients with severe or generalized periodontal disease had adjusted odds ratios (95 percent confidence interval[CI] of 4.45 (2.16-9.18) for preterm delivery.