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The study analysed primary breast cancer tissues for PTPRO promoter hypermethylation and evaluated potential relations to pathological features and patient outcome, in addition to its potential as a breast cancer biomarker.
Among matched peripheral blood samples from breast cancer patients, 33, or 34%, of 98 exhibited methylated PTPRO in plasma.
PTPRO methylation was positively correlated with lymph node involvement (P = 0.014), poorly differentiated histology (P = 0.037), depth of invasion (P = 0.004) and HER2 amplification (P = 0.001).
Nephrin, podocin, synaptopodin, podocalyxin, CD2AP, ACTN4 (encodes for [alpha]-actinin 4), PTPRO (encodes for GLEPP-1), and WT1 mRNA have been isolated from urine of patients with varying glomerulopathies.
Gillespie et al., "Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate," The Journal of Clinical Investigation, vol.
The study named "Disruption of PTPRO Causes Childhood-Onset Nephrotic Syndrome" has been published in the latest edition of The American Journal of Human Genetics as well.
Speaking to AA on the study, Ozaltin said the discovery would help physicians diagnose and treat patients with mutation of the PTPRO gene at early phases, and eventually slow-down the progress of or even prevent end-stage kidney failure.
 screened about 9000 antigens in pretransplant sera of FSGS and pretransplant elevation of anti-CD40 antibody (Ab) alone had the best correlation (78% accuracy) with recurrent FSGS risk after KT among seven Abs (CD40, PTPRO, CGB5, FAS, P2RY11, SNRPB2, and APOL2).
Goyal et al., "Antibodies to protein tyrosine phosphatase receptor type O (PTPro) increase glomerular albumin permeability (Palb)," American Journal of Physiology--Renal Physiology, vol.
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