PTTG expression level was significantly higher in NFPA compared to somatotropinomas (P=0.04, Table 1) and was associated with tumor invasiveness (P=0.03), especially in NFPA (P=0.02; Figure 1).
The present study evaluated clinical, laboratory, and GNAS, AIP, and PTTG molecular data of 62 apparently sporadic pituitary adenomas followed in a single endocrine tertiary-referral center.
The PTTG expression observed in our cohort was high in almost all patients and was related significantly to invasiveness (p=0.03), particularly for NFPA (P=0.02).
In conclusion, our results are in agreement with previous results that point to PTTG expression as a useful molecular marker for pituitary tumor invasiveness, particularly for NFPA.
Expression of pituitary tumour transforming gene (PTTG) and fibroblast growth factor-2 (FGF-2) in human pituitary adenomas: relationships to clinical tumour behaviour.
Relationship of PTTG expression with tumor invasiveness and microvessel density of pituitary adenomas: a meta-analysis.
The relationship between pituitary tumour transforming gene (PTTG) expression and in vitro hormone and vascular endothelial growth factor (VEGF) secretion from human pituitary adenomas.
Recently a meta-analysis suggested that PTTG expression may be associated with tumor invasiveness and microvessel density of pituitary adenomas .
PTTG. When compared to female wild-type mice, pituitaries from female [Drd2.sup.-/-] mice had decreased PTTG concentration .
Taken together these results suggest that angiogenesis of pituitary tumors in the [Drd2.sup.-/-] mice does not depend on FGF-2 and PTTG expression.
Boelaert et al., "Expression of pituitary tumour transforming gene (PTTG) and fibroblast growth factor-2 (FGF-2) in human pituitary adenomas: relationships to clinical tumour behaviour," Clinical Endocrinology, vol.
Goya et al., "PTTG expression in different experimental and human prolactinomas in relation to dopaminergic control of lactotropes," Molecular Cancer, vol.